Research

I completed my PhD at the University of Warwick, School of Life Sciences. My research efforts combined the two fields of structural biology and neuroscience to investigate how proteins related to neurodegenerative disease alter neuron behavior in the brain. Understanding the exact mechanism of toxicity could help reveal new treatment strategies for neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

 

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Research at the University of Manchester

I have worked as a postdoctoral research associate at the University of Manchester to investigate interactions with the microtubule motor complex: Dynein.

Dynein is a vital component of the cell's transport system; being responsible for moving vesicles, chromosomes and organelles around the cell. Dynein performs this incredible nanomechanical function by using its 'legs' to physically 'walk' along the microtubules that make up the cell's cytoskeleton.

Dynein is able to bind to its various cargoes by interacting with adaptor proteins. Recently, the protein KASH5, which sits in the outer nuclear membrane, was shown to interact with dynein and link it to the ends of chromosomes in the nucleus. In doing so, dynein and KASH5 are likely to play important roles in cell division and meiosis.

The aim of this on going research was to characterise the interaction of KASH5 with the dynein complex and investigate the behavior of KASH5 during cell division.

Cell division: Two nuclei formed inside a single cell.

(blue = nucleus; red = microtubules; green = nuclear envelope)

Dr Timothy J Kaufmann

All content within this portfolio is © 2016 by Tim Kaufmann.

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